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Total Protein with Albumin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the ratio of total protein to albumin in your blood serum, which helps assess protein balance and potential liver or kidney function issues.

Quick summary

["Understanding your protein balance can help detect hidden health concerns like liver disease or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111298-6
Short code
T palldm IgG Msmt Ser
Synonyms
T palldm IgG Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your body relies on proteins, including albumin, to maintain fluid balance, support immune function, and transport nutrients. A ratio that deviates from expected levels may signal problems with protein production or loss, often linked to conditions like cirrhosis, kidney disease, or malnutrition.

How the Test Works

Blood is drawn and processed to separate serum, where protein levels are measured. Albumin is specifically analyzed to calculate the ratio against total protein. This method helps identify imbalances without needing separate tests for each component.

Common Conditions Monitored

This ratio is often used to monitor liver function (e.g., cirrhosis), kidney function (e.g., nephrotic syndrome), or chronic diseases like diabetes. It can also reflect nutritional status or response to treatments like dialysis.

Sample Preparation

No special preparation is needed. You may be asked to fast for 8–12 hours before the test, but this depends on your healthcare provider’s instructions. Bring any medications or supplements you’re taking to discuss with your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein-Albumin Ratio

Frequently asked questions

What does a high or low ratio mean?
A high ratio may indicate dehydration, inflammation, or conditions like multiple myeloma, where protein production is disrupted. A low ratio often suggests liver disease (reduced albumin synthesis), kidney disease (protein loss), or malnutrition.
How often should I get this test?
Your doctor will determine frequency based on your health history, symptoms, or treatment plan. Regular monitoring may be recommended if you have chronic liver/kidney disease or other conditions affecting protein balance.
Can I eat or drink before this test?
Typically, fasting is not required, but follow your provider’s guidance. If you’re unsure, ask before your appointment to avoid delays.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy