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Total Protein with Albumin-to-Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein levels and compares albumin to globulin proteins, which can help assess protein balance, kidney function, or liver health.

Quick summary

["Your blood’s protein balance may signal underlying health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47361-1
Short code
T palldm IgG Ser Donr Ql IA
Synonyms
T palldm IgG Ser Donr Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Total protein includes albumin and globulin, both vital for transporting nutrients, maintaining fluid balance, and supporting immune function. The albumin-to-globulin (AG) ratio compares these two protein types, which can reflect conditions like malnutrition, inflammation, or organ dysfunction.

Why Might You Need This Test?

Doctors may order this test to evaluate protein loss (e.g., kidney disease), liver function, nutritional status, or chronic inflammation. It can also help diagnose conditions like nephrotic syndrome or chronic liver disease.

How Is the Sample Collected?

A blood sample is drawn from a vein, typically in your arm. The serum (liquid part after clotting) is analyzed for protein composition and the AG ratio.

What Are Common Reasons for Testing?

Common reasons include suspected kidney disease, unexplained weight loss, chronic illness, or symptoms like swelling, fatigue, or frequent infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Abnormal results may indicate protein malnutrition, liver/kidney disease, or inflammatory conditions. Low albumin often signals fluid retention or poor nutrition, while elevated globulins may reflect immune activation or chronic disease.

Short name

Total Protein & AG Ratio

Frequently asked questions

What do my total protein and AG ratio results mean?
Results alone don’t provide a diagnosis—your doctor will consider your symptoms, medical history, and other test results. For example, a low AG ratio might suggest liver disease, while high globulins could hint at infection or autoimmune conditions.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times.
Can I eat or drink before this test?
No special preparation is needed. However, avoid alcohol for 24 hours before testing, as it may affect protein levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy