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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help assess overall health and detect potential issues like malnutrition or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17726-1
Short code
T palldm IgG Ser Ql IF
Synonyms
T palldm IgG Ser Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions affecting protein production, absorption, or kidney function. It can also help diagnose or monitor diseases like liver disease, malnutrition, or certain infections.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours if your blood is drawn early in the morning. Wear a loose shirt for easy access.

What Happens During the Test?

A healthcare provider will insert a small needle into a vein in your arm to draw a blood sample. You may feel a brief pinch, but it’s usually over quickly. The blood is sent to a lab for analysis.

What Are Possible Results?

Results are reported in grams per deciliter (g/dL). Lower than expected levels may indicate malnutrition, kidney disease, or liver problems, while higher levels could suggest dehydration or conditions like multiple myeloma.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Total Protein Levels

Short name

Total Protein

Frequently asked questions

What Does It Mean If My Results Are Abnormal?
If your total protein is lower than expected, your doctor may investigate causes like poor nutrition, chronic kidney disease, or liver disorders. If it’s higher, they might check for conditions like severe dehydration or certain cancers.
How Often Should I Get This Test?
Your doctor will determine how often you need this test based on your health history, symptoms, and other tests. Regular checks may be recommended if you have conditions like kidney disease or liver problems.
Can I Eat or Drink Before the Test?
Typically, no special diet is required, but fasting may be advised if your blood is drawn early in the morning. Always follow your doctor’s instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy