Total Protein with Albumin-to-Globulin Ratio (Serum/Plasma)
This test measures your blood’s total protein levels and compares albumin to globulin, two key protein groups that help maintain fluid balance and support immune function.
["Understanding your protein balance can help identify fluid imbalances or immune issues."]
Key facts at a glance
- LOINC
- 98217-3
- Short code
- T palldm IgG Titr CSF IF
- Synonyms
- T palldm IgG Titr CSF IF
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Ref low
- 8
- Ref high
- 61
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- if
- CPT
- 82977
- SNOMED
- 3110003
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
What Does Total Protein Measure?
Total protein includes albumin and globulin, both vital for transporting nutrients, maintaining blood pressure, and supporting immune responses. Abnormal levels may signal conditions like dehydration, liver disease, or chronic inflammation.
How Albumin-to-Globulin Ratio Works
The ratio compares albumin (a protein that helps retain fluids) to globulin (proteins involved in immunity and clotting). A higher albumin-to-globulin ratio often suggests conditions like malnutrition or liver disease, while a lower ratio may indicate chronic infections or kidney problems.
Why This Test Matters in Your Health
This test helps doctors assess fluid balance, detect protein-related disorders, and evaluate conditions affecting liver, kidney, or immune function. It’s sometimes used alongside other tests to diagnose or monitor chronic illnesses.
Common Conditions This Test Helps Identify
Abnormal results may signal dehydration, liver disease (e.g., cirrhosis), kidney disease, malnutrition, or chronic infections. High protein levels could indicate dehydration, while low levels may point to liver or kidney issues.
Reference range
Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical significance: This test provides a snapshot of protein metabolism and immune function, guiding decisions for managing conditions like chronic kidney disease, liver disorders, or malnutrition. It’s often used as part of a broader diagnostic evaluation.
Short name
Protein & Alb/Glob Ratio
Frequently asked questions
What does a high or low total protein level mean?
How is this test performed?
Do I need to prepare for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy