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Total Protein with Albumin and Globulin Separation (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein in blood and breaks it down into albumin and globulin fractions, which help assess protein balance and potential health issues.

Quick summary

["Helps identify protein disorders, nutritional deficiencies, or kidney/immune system problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98223-1
Short code
T palldm IgM bands Ser IB
Synonyms
T palldm IgM bands Ser IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to check for conditions like malnutrition, liver disease, kidney problems, or immune system disorders. It can also help monitor chronic conditions like heart failure or certain cancers.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Total protein combines albumin and globulin. Low levels may suggest malnutrition or liver/kidney issues, while high levels could indicate dehydration, inflammation, or certain cancers. Albumin specifically helps maintain fluid balance in your body.

Common Conditions Monitored

This test is often used to diagnose or track conditions like chronic kidney disease, liver disease, malnutrition, or autoimmune diseases. It can also help evaluate response to treatments for these conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein balance is critical for tissue repair, immune function, and fluid regulation. Abnormal levels may signal underlying health concerns that need further evaluation, such as blood tests or imaging.

Short name

Total Protein Profile

Frequently asked questions

What does a low total protein level mean?
A low total protein level may indicate conditions like malnutrition, liver disease, or kidney problems. Your provider will discuss results with you and may recommend additional tests if needed.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab. Your provider will contact you with the final report.
Can diet affect these results?
Diet can influence protein levels, especially if you’re eating poorly or have certain medical conditions. Avoid extreme dietary changes before testing, and follow your provider’s advice.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy