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Total Protein with Albumin-to-Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein levels in blood and evaluates the balance between albumin and globulin proteins, which can help assess kidney function, liver health, and immune status.

Quick summary

["Your blood protein balance may signal underlying health concerns that need attention."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17728-7
Short code
T palldm IgM Ser IF-aCnc
Synonyms
T palldm IgM Ser IF-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors order this test to diagnose or monitor conditions affecting protein production, such as kidney disease, liver disorders, malnutrition, or chronic inflammation. It may also be used to check for protein-losing conditions or to evaluate the effectiveness of treatments.

What to Expect Before the Test

No special preparation is needed, but avoid heavy meals 2 hours before the blood draw. Stay hydrated but limit fluids 1 hour beforehand to ensure accurate results.

What the Results Indicate

Total protein reflects the combined weight of albumin and globulin. An elevated level may suggest dehydration or conditions like multiple myeloma, while low levels could indicate kidney disease, liver failure, or severe malnutrition. The albumin-to-globulin ratio compares these proteins—high globulins may signal chronic inflammation or immune disorders.

Common Conditions Monitored

This test helps identify kidney dysfunction (e.g., nephrotic syndrome), liver disease (e.g., cirrhosis), autoimmune diseases (e.g., rheumatoid arthritis), or protein-losing gastrointestinal disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein Balance and Health Risks

Short name

Protein & Albumin-Globulin Ratio Test

Frequently asked questions

What causes abnormal protein levels?
Abnormal results may stem from medical conditions like kidney disease, liver failure, infections, or chronic inflammation. Lifestyle factors (e.g., poor nutrition, excessive alcohol) can also impact protein levels.
How often should I get this test?
Frequency depends on your health status. Doctors may recommend periodic testing for chronic conditions (e.g., kidney disease) or after treatments affecting protein metabolism.
Can diet affect my protein test results?
Yes—high-protein diets or deficiencies may alter results. Avoid extreme dietary changes before testing to ensure accurate measurements.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy