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Anti-neutrophil cytoplasmic antibody (ANCA) profile by immunoassay (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures specific antibodies in your blood that may indicate an inflammatory condition called vasculitis, which affects small blood vessels. These antibodies target proteins inside or on the surface of neutrophils (a type of white blood cell).

Quick summary

["This test helps diagnose or monitor certain autoimmune diseases affecting blood vessels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
106999-6
Short code
T.pallidum Ab.IgM 257 Ser Ql IB
Synonyms
T.pallidum Ab.IgM 257 Ser Ql IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The ANCA test detects two main types of antibodies: **c-ANCA** (anti-proteinase 3) and **p-ANCA** (anti-myeloperoxidase). These antibodies are linked to different forms of vasculitis, such as Wegener’s granulomatosis or microscopic polyangiitis. The test uses an immunoassay method to identify these antibodies in your serum or plasma.

Why Might You Need This Test?

Your doctor may recommend this test if you have symptoms like persistent sinus or lung infections, unexplained skin rashes, joint pain, or organ damage (e.g., kidney issues). It’s also used to monitor treatment progress in patients with known vasculitis.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum or plasma for testing. Results are typically available within 1–3 business days.

Common Conditions Linked to Positive Results

Positive ANCA results may suggest vasculitis, but other conditions (like infections or certain medications) can also cause false positives. Your doctor will consider your symptoms, medical history, and other test results for diagnosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

ANCA Test

Frequently asked questions

What are the normal results for this test?
There are no standard reference ranges for ANCA levels alone—results are interpreted in the context of your symptoms, medical history, and other tests. A positive result (detecting ANCA antibodies) may prompt further evaluation for vasculitis or related conditions.
How long does it take to get my results?
Results are usually available within 1–3 business days after your blood sample is processed. Your doctor will discuss the findings with you during your follow-up visit.
Can I take anything special before this test?
No special preparations are needed. However, inform your doctor about any medications (including supplements) or recent infections you’ve had, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy