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Immunoassay for Anti-IGG4 Antibodies (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies directed against the Immunoglobulin G4 (IGG4) protein in your blood. It may help diagnose or monitor conditions linked to abnormal IGG4 levels, such as IgG4-related disease.

Quick summary

["This test helps identify potential autoimmune or inflammatory conditions tied to IGG4 antibodies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107000-2
Short code
T.pallidum Ab.IgM 44 Ser Ql IB
Synonyms
T.pallidum Ab.IgM 44 Ser Ql IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like swelling, pain, or organ involvement (e.g., pancreas, liver, or lymph nodes) that could suggest IgG4-related disease. It may also be used to track disease activity or response to treatment in known cases.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, typically drawn from a vein in your arm. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Results are qualitative (positive/negative) rather than numeric. A positive test indicates the presence of anti-IGG4 antibodies, which may support a diagnosis of IgG4-related disease. Further evaluation with imaging or biopsy may be needed for confirmation.

Common Conditions Monitored

This test is primarily used to diagnose or monitor IgG4-related diseases, such as pancreatitis, liver disease, or lymphadenopathy. It’s not a routine screening test for the general population.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: IgG4-Related Disease

Short name

Anti-IGG4 Antibody Test

Frequently asked questions

What are the typical symptoms of IgG4-related disease?
Symptoms vary widely but often include persistent swelling (e.g., in the pancreas, liver, or lymph nodes), pain, or organ dysfunction. Some people may have no symptoms at all.
How is IgG4-related disease treated?
Treatment typically involves corticosteroids or other immunosuppressive medications to reduce inflammation. Your doctor may adjust treatment based on test results and symptoms.
Can this test be done at home?
No, this test requires a blood sample collected by a healthcare professional in a clinical setting.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy