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Immunoassay for Anti-IGG4 Antibodies (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies directed against Immunoglobulin G4 (IGG4), a type of antibody involved in certain autoimmune and inflammatory conditions.

Quick summary

["Assessing antibody levels may help diagnose or monitor conditions linked to abnormal immune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
106998-8
Short code
T.pallidum Ab.IgM 453 Ser Ql IB
Synonyms
T.pallidum Ab.IgM 453 Ser Ql IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have symptoms or conditions associated with IGG4-related diseases, such as autoimmune pancreatitis, lymphocytic infiltration of organs, or other systemic inflammatory disorders. It can also be used to monitor treatment progress in patients already diagnosed with these conditions.

What to Expect Before the Test

No special preparation is typically needed. You may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Bring any medications or supplements you’re currently taking to your appointment.

How the Test Is Performed

A healthcare provider will draw blood from a vein in your arm using a small needle. The blood sample will be sent to a lab for analysis using an immunoassay method to detect specific antibodies against IGG4.

What the Results Mean

Results are qualitative (positive/negative) and indicate whether detectable levels of anti-IGG4 antibodies are present. Elevated levels may suggest an underlying IGG4-related disease, but further evaluation is needed to confirm diagnosis and guide treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Anti-IGG4 Antibody Test

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains antibodies against IGG4, which may indicate an underlying condition like IGG4-related disease. This does not definitively diagnose the disease alone—your doctor will use the result alongside other tests and symptoms to guide further evaluation.
Can lifestyle changes affect this test?
Generally, lifestyle factors like diet or exercise do not directly influence antibody levels measured in this test. However, if you’re on medications (e.g., steroids, immunosuppressants), your doctor may adjust timing or frequency of testing to avoid interference.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your healthcare provider will contact you once results are ready, so keep their contact information handy.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy