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Total Protein and Albumin Ratio (with Immunoglobulin G and Fibrinogen Quantification)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein, albumin, immunoglobulin G (IgG), and fibrinogen levels, which help assess protein balance, immune function, and blood clotting capacity.

Quick summary

["Understanding your protein and immune-related blood components can help identify issues like malnutrition, infections, or clotting disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98219-9
Short code
T pall IgG + IgM + bands Pnl CSF IB
Synonyms
T pall IgG + IgM + bands Pnl CSF IB
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to evaluate protein levels in your blood, which can indicate conditions such as liver disease, kidney problems, infections, or malnutrition. It may also help assess immune function or blood clotting risks.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before drawing blood. Wear a loose shirt for easy access to your arm.

What the Results Mean

Abnormal results may signal low or high protein levels, which could point to conditions like severe infections, liver disease, or protein-losing syndromes. IgG and fibrinogen levels help assess immune response and clotting ability.

Common Conditions Linked to These Tests

High or low protein levels can occur with chronic diseases, kidney or liver dysfunction, or certain immune disorders. IgG levels may rise with infections or autoimmune diseases, while fibrinogen helps detect bleeding or clotting disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein, Albumin, IgG, Fibrinogen Profile

Frequently asked questions

What does a high total protein level mean?
A high total protein level may suggest dehydration, multiple myeloma (a blood cancer), or conditions that increase blood proteins like chronic inflammation or certain cancers. Your doctor will consider other test results and symptoms for diagnosis.
How do albumin and IgG levels relate to health?
Low albumin levels often point to liver disease, kidney problems, or malnutrition, as the body struggles to produce enough protein. IgG levels reflect long-term immune health—low levels may indicate weakened immunity, while high levels can signal chronic infections or autoimmune responses.
Why might fibrinogen be tested?
Fibrinogen is measured to assess blood clotting function. Low levels may indicate bleeding disorders or liver issues, while high levels could suggest inflammation or clotting risks, such as in pregnancy or certain cancers.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy