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Total Protein with Albumin-to-Globulin Ratio (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein levels in your blood and evaluates the balance between albumin and globulin proteins, which can help assess overall protein status and potential immune or liver function issues.

Quick summary

["Understanding your protein balance may help identify conditions like malnutrition, liver disease, or immune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98213-2
Short code
T pall IgG + IgM + bands Pnl Ser IB
Synonyms
T pall IgG + IgM + bands Pnl Ser IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Measured?

Total protein is the sum of all proteins in your blood, including albumin and globulin. Albumin is a key protein that helps maintain fluid balance in your body, while globulins are involved in immune function and transport of substances like hormones and metals. This test provides a ratio to compare these two protein types.

Why It Matters in Your Health?

Abnormal protein levels or ratios can signal underlying health concerns. Low total protein or low albumin might indicate malnutrition, liver disease, or kidney problems, while high globulin levels could suggest chronic inflammation or immune system activity.

Sample Preparation and Testing Process

A blood sample is drawn from a vein, typically in the arm. The sample is processed to separate serum or plasma, where protein levels are measured using a specialized laboratory technique. This test is usually done as part of a routine blood panel.

Common Conditions This Test Helps Diagnose

This test can help diagnose or monitor conditions such as liver disease (e.g., cirrhosis), kidney disease, malnutrition, chronic infections, or autoimmune disorders. It may also be used to assess protein-losing conditions like gastrointestinal bleeding or proteinuria.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein & Albumin-Globulin Ratio

Frequently asked questions

What does a low or high total protein level mean?
A low total protein level may suggest conditions like malnutrition, liver disease, or kidney problems. A high total protein level could indicate dehydration, multiple myeloma, or severe infections. Your doctor will interpret these results in the context of your overall health and symptoms.
How often should I get this test?
Your doctor may recommend this test periodically if you have conditions like liver disease, kidney disease, or chronic infections. It’s also sometimes included in routine health check-ups or when monitoring treatment for certain conditions. Follow your healthcare provider’s advice for scheduling.
Can diet or lifestyle changes affect protein levels?
Yes, diet and lifestyle can influence protein levels. Eating a balanced diet rich in protein can help maintain healthy levels. Conditions like chronic kidney disease or liver disease may require dietary adjustments to support protein metabolism. Always discuss dietary changes with your healthcare provider before making significant modifications.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy