Genetic mutation analysis for *Tumor Protein p53* (TP53) in a blood sample
This test checks for specific changes (mutations) in the TP53 gene, which is involved in controlling cell growth and repair. Mutations in this gene may be linked to certain cancers.
["A TP53 mutation test helps identify genetic changes that could increase cancer risk or confirm a diagnosis in some cases."]
Key facts at a glance
- LOINC
- 93193-1
- Short code
- TPMT + NUDT15 Mut Anl Bld/T
- Synonyms
- TPMT + NUDT15 Mut Anl Bld/T
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you have a family history of cancer, symptoms that suggest a genetic predisposition, or if you’ve been diagnosed with a cancer linked to TP53 mutations (e.g., certain types of lung, breast, or colorectal cancer). It may also be used in research or clinical trials.
What to Expect Before the Test
No special preparation is usually needed. You’ll provide a blood sample, typically drawn from a vein in your arm. The process is quick and similar to other blood tests.
What the Results Mean
Results can be positive (mutation detected), negative (no mutation found), or inconclusive. A positive result may require further testing or genetic counseling to discuss implications.
Common Conditions Linked to TP53 Mutations
Mutations in TP53 are associated with several cancers, including but not limited to: lung cancer, breast cancer, colorectal cancer, and Li-Fraumeni syndrome (a rare genetic disorder). These mutations can also affect non-cancerous conditions like certain types of tumors or skin changes.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
TP53 is one of the most commonly mutated genes in human cancers. While not all TP53 mutations lead to cancer, they can increase susceptibility or help confirm a diagnosis in certain cases. Genetic testing may guide treatment options, such as targeted therapies or surveillance strategies, depending on the context.
Short name
TP53 Mutation Test (Blood)
Frequently asked questions
Will this test show all types of cancer?
Can I have my results explained by my doctor?
Does this test require fasting?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy