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Serum or plasma concentration of total protein (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Total protein levels can indicate overall health, hydration status, or potential protein-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50669-1
Short code
Trans AT III Vol Patient
Synonyms
Trans AT III Vol Patient
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Total Protein Used For?

Healthcare providers use total protein levels to assess how well your body is retaining fluids, managing infections, or responding to chronic conditions like kidney disease or liver problems. It can also help diagnose conditions like malnutrition or certain autoimmune diseases.

How Is the Test Performed?

A small blood sample is drawn from your arm. The blood is processed to separate serum (if clotted) or plasma (if anticoagulated) for testing. The protein content is measured using a specialized laboratory technique, often automated and standardized.

What Does a Result Mean?

Results may be compared to general reference ranges, but individual values can vary based on age, health status, and other factors. Abnormally high or low levels may signal underlying health concerns that need further evaluation.

Common Causes of Abnormal Results

High total protein levels might occur with dehydration, multiple myeloma, or severe infections. Low levels can suggest malnutrition, kidney disease, liver failure, or excessive fluid loss. Your doctor will consider your full medical picture to interpret results accurately.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

Why might my doctor order this test?
Your doctor may order total protein testing to monitor conditions like kidney disease, liver disease, malnutrition, or to evaluate symptoms such as swelling, fatigue, or unexplained weight loss. It can also be part of routine check-ups or investigations for autoimmune disorders.
What should I do if my results are outside the normal range?
If your results are abnormal, your doctor will discuss them with you and may recommend additional tests or treatments. Follow their guidance carefully, as this could indicate a need for further evaluation or management of a health condition.
Can diet or lifestyle affect my total protein test results?
Yes, diet, hydration status, and certain medications can influence protein levels. Avoid alcohol or high-protein supplements before the test if instructed, and stay well-hydrated unless advised otherwise.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy