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Urine Total Protein to Creatinine Ratio (24-Hour Collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the ratio of protein and creatinine in your urine over 24 hours to help assess how much protein your kidneys are losing.

Quick summary

["Helps detect kidney damage by checking protein loss in urine over a full day’s output."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46136-8
Short code
Trans Cells #/area UrnS LPF
Synonyms
Trans Cells #/area UrnS LPF
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
microscopy-light-lpf
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like swelling, frequent urination, or unexplained weight changes, or if they suspect kidney problems. It’s also used to monitor kidney function in people with diabetes, high blood pressure, or other conditions that can affect the kidneys.

What to Expect Before the Test

You’ll collect all your urine for 24 hours, typically starting after midnight one day and ending the same time the next day. Store the urine in a refrigerator until you deliver it to the lab. Drink plenty of fluids but avoid foods that might affect urine color (like beets or berries).

What Happens During the Test

No special preparation is needed beyond collecting urine. The lab will analyze the total protein and creatinine levels in your urine sample to calculate the ratio.

What the Results Mean

A higher ratio may indicate kidney damage or disease, while a normal ratio suggests healthy kidney function. Your doctor will interpret the results in relation to your overall health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

24-Hour Urine Protein-to-Creatinine Ratio

Frequently asked questions

How often should I collect urine for this test?
Collect urine continuously for a full 24-hour period, starting after midnight one day and ending at the same time the next day. This ensures an accurate representation of your daily protein excretion.
Can I eat or drink anything special before this test?
No special diet is required, but avoid foods that might stain urine (like beets or cranberries) or interfere with results. Drink as much water as you normally would to help flush your system.
What if I miss part of the urine collection?
If you miss any urine during the 24-hour period, you’ll need to restart the collection. It’s important to complete the full 24 hours for accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy