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Total Protein in Serum (or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps your body stay healthy by transporting nutrients, fighting infections, and maintaining fluid balance.

Quick summary

["Your blood protein levels can signal health issues or guide treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10418-2
Short code
Trans Fact IX Vol Patient
Synonyms
Trans Fact IX Vol Patient
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Blood proteins, including albumin and globulins, are essential for many bodily functions. Low levels may indicate conditions like malnutrition, kidney disease, or liver problems, while high levels could suggest dehydration or certain inflammatory diseases. This test helps doctors assess overall health and diagnose potential problems early.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your doctor know before the test.

Common Conditions Affecting Results

Low protein levels might be linked to conditions like chronic kidney disease, severe infections, or poor nutrient absorption. High levels could result from dehydration, multiple myeloma, or certain liver disorders. Your doctor will discuss results in the context of your medical history.

What Your Results Mean

Your results will be compared to standard ranges for your age and health. If your levels are outside the normal range, your doctor may recommend further testing or adjustments to your treatment plan.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

Will fasting affect this test?
No, fasting is not required for this test. Blood protein levels can vary slightly based on hydration and recent meals, but they’re not affected by eating or drinking before the test.
Can diet impact my protein levels?
Yes, diet can influence protein levels. Eating a balanced diet rich in protein may help maintain healthy levels, while poor nutrition or certain medical conditions can lower them. Your doctor may suggest dietary changes if needed.
How often should I get this test?
The frequency depends on your health status. Your doctor will determine how often to check your protein levels based on your symptoms, medical history, and any ongoing treatments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy