Serum/plasma mass concentration of donor-specific antibodies (DSA) for pre-transplant antibody screening

Why This Test Matters for Transplant Preparation

Transplant teams use this screening to identify if your immune system has developed antibodies that could attack a donated organ. These antibodies, called donor-specific antibodies (DSAs), are often detected through blood tests before a transplant procedure. Finding them early allows for careful matching of donors and organs to minimize rejection risks.

How the Test Works

Your blood sample is tested using a sensitive immunoassay method to detect specific antibodies that target proteins on donor organ cells. The test measures the concentration of these antibodies to determine compatibility.

What to Expect Before Your Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it involves a blood draw. Wear comfortable clothing and bring your identification. Your healthcare provider will explain the process and answer any questions.

Common Reasons for This Test

This test is typically ordered if you have a history of organ transplants, autoimmune diseases, or blood transfusions, as these conditions can increase your risk of developing DSAs. It’s also used in pre-transplant evaluations to assess immune compatibility.