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Total IgG Immunoglobulin (Serum/plasma Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin G (IgG), the most common type of antibody in your blood. IgG helps protect your body from infections and diseases.

Quick summary

["IgG antibodies are vital for long-term immunity and are often checked if you have concerns about immune function or recurrent infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35363-1
Short code
Trig in Chylo SerPl-mCnc
Synonyms
Trig in Chylo SerPl-mCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like frequent infections, low energy, or if you’re being evaluated for conditions like immunodeficiency, autoimmune diseases, or certain infections. It can also be part of routine monitoring for people with chronic illnesses or those receiving treatments that affect immunity.

What to Expect Before the Test

No special preparation is usually needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Results are compared to a general reference range for healthy adults. Very high or very low levels may signal underlying health issues, but individual results depend on your overall health and medical history.

Common Conditions Linked to IgG Levels

Low IgG levels can indicate weakened immunity, while very high levels may suggest chronic inflammation, certain infections, or overactive immune responses. Your provider will discuss these findings with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Level

Frequently asked questions

What causes IgG levels to be too low?
Low IgG levels can result from conditions that affect your immune system, such as primary immunodeficiency, certain cancers, long-term infections, or treatments like chemotherapy. Lifestyle factors like poor nutrition or chronic stress may also play a role.
What happens if my IgG levels are outside the normal range?
If your IgG levels are abnormal, your healthcare provider will review your medical history and symptoms to determine the cause. They may recommend additional tests or treatments to address potential issues, such as adjusting medications or improving immune support.
Can diet or supplements affect IgG levels?
While diet and supplements can support overall immune function, they typically do not directly alter IgG levels. Focus on a balanced diet rich in vitamins, minerals, and proteins to help maintain immune health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy