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Total Cholesterol (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of cholesterol in your blood, which includes both HDL (good) and LDL (bad) cholesterol. Cholesterol is a fat-like substance that plays a key role in your body’s health.

Quick summary

["Your total cholesterol level helps assess your risk for heart disease and other health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
70218-3
Short code
Trigl Bld-sCnc
Synonyms
Trigl Bld-sCnc
Category
glucose
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Cholesterol is essential for cell membrane structure and hormone production, but having too much can increase your risk of heart disease, stroke, or other serious health problems. High cholesterol often has no symptoms, so regular testing is important.

What to Expect Before the Test

You’ll typically have a small needle inserted into your arm to draw blood. This is a quick and usually painless procedure. Avoid eating or drinking for at least 12 hours before the test if instructed by your healthcare provider.

How the Test Works

Your blood sample is sent to a lab where it’s analyzed to measure the total cholesterol concentration. The test doesn’t require special preparation beyond fasting if directed.

What the Results Mean

Results are usually reported as a single number (total cholesterol level) rather than separate HDL or LDL values. Your doctor will interpret the results in relation to your overall health and risk factors.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Cholesterol

Frequently asked questions

What causes high cholesterol?
High cholesterol can be influenced by genetics, diet high in saturated or trans fats, lack of physical activity, obesity, smoking, or certain medical conditions like diabetes. Lifestyle changes, medications, or both may be recommended to manage it.
How often should I get this test?
Your doctor will determine how often you need cholesterol testing based on your age, risk factors, and overall health. Typically, adults with no risk factors may get tested every 4–5 years, while those with higher risk factors may need more frequent testing.
Can diet alone lower cholesterol?
Yes! Eating more fruits, vegetables, whole grains, and healthy fats (like olive oil or nuts) while reducing saturated and trans fats can help lower cholesterol. Exercise, weight management, and avoiding smoking also play a key role.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy