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Trimethoprim Concentration in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of the antibiotic trimethoprim in your blood, often taken to monitor drug levels in treatment plans.

Quick summary

["Trimethoprim levels help ensure the medication is working effectively and avoid unnecessary exposure."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72937-6
Short code
Trimethoprim (neut) IgM SerPl Ql FC
Synonyms
Trimethoprim (neut) IgM SerPl Ql FC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re taking trimethoprim (or a combination with sulfamethoxazole) to check whether the medication is at an appropriate level in your blood. This is especially important for managing infections like urinary tract infections, respiratory infections, or certain parasitic diseases.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for a few hours before the blood draw if your test involves fasting-related measurements. Bring a list of all medications, including over-the-counter drugs and supplements, to share with your provider.

During the Test

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause discomfort. The process takes a few minutes, and you can resume normal activities afterward.

Possible Results and Interpretation

Results are compared to standard ranges for trimethoprim in blood, though exact values can vary based on your medical condition, dosage, and other factors. Your provider will discuss the results with you and explain what they mean in the context of your treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low levels of trimethoprim may indicate insufficient medication absorption or resistance to the drug, potentially requiring dose adjustments. High levels could signal toxicity or improper dosing, prompting further evaluation. This test is critical for optimizing therapy and preventing complications.

Short name

Trimethoprim Level

Frequently asked questions

What does a low trimethoprim level mean?
A low level might suggest the medication isn’t working as intended, possibly due to poor absorption, drug interactions, or incorrect dosing. Your provider may adjust your treatment plan, such as increasing the dose or changing the medication.
How often should I get this test?
Frequency depends on your treatment plan. For long-term use, your provider may recommend monitoring every few weeks or months to ensure the drug remains effective and safe. Follow your healthcare team’s instructions.
Can I eat or drink before the test?
Typically, no fasting is required unless specified by your provider. However, always check with them beforehand, as some tests may have specific guidelines for food or drink intake.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy