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Serum or Plasma Protein Electrophoresis (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of different protein types in your blood, helping identify abnormalities in protein levels that may signal conditions like infections, kidney disease, or certain cancers.

Quick summary

["This test helps diagnose and monitor conditions affecting protein balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13496-5
Short code
Tri-Phos Cry Stone Micro
Synonyms
Tri-Phos Cry Stone Micro
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
microscopy-light
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test separates blood proteins into five main fractions: albumin, alpha-1 globulins, alpha-2 globulins, beta globulins, and gamma globulins. Each fraction may contain proteins involved in immunity, clotting, transport, or inflammation. Variations can indicate underlying health issues.

Why It’s Ordered

Your healthcare provider may order this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if tests suggest conditions like multiple myeloma, lymphoma, chronic inflammation, or kidney disease. It’s also used to monitor treatment progress in certain conditions.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is placed in a tube and sent to the lab, where it’s analyzed using gel electrophoresis. No special preparation is needed, but fasting may be advised depending on your specific test instructions.

Common Conditions Detected

Abnormal results may reveal elevated or low levels of specific proteins, which can signal conditions such as multiple myeloma (overproduction of abnormal antibodies), liver disease (reduced albumin), or infections (increased acute-phase proteins).

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Protein Electrophoresis (Serum/Plasma)

Frequently asked questions

How long does it take to get my results?
Results are typically available within 24 to 48 hours, depending on your lab’s processing schedule. Follow-up with your healthcare provider to discuss findings.
Can I eat or drink before this test?
No special diet is required, but always check with your provider for any specific instructions. Fasting may be advised for certain related tests, so confirm with them.
Is there any risk or discomfort with this test?
Minimal discomfort is possible from the needle insertion, which usually fades quickly. Rarely, there may be bruising or slight pain. If you experience excessive bleeding or pain, contact your provider immediately.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy