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Thyroid Stimulating Hormone (TSH) with Serum/Plasma Measurement by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of thyroid-stimulating hormone (TSH) in your blood. TSH helps regulate your thyroid hormone levels, which are important for metabolism, energy, and overall health.

Quick summary

["TSH helps regulate your thyroid function and can signal if your thyroid is underactive or overactive."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12934-6
Short code
TSH 15M p chal SerPl-aCnc
Synonyms
TSH 15M p chal SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.4
Ref high
4
Critical range
0.1 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84443
SNOMED
301343003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order a TSH test to check for thyroid problems, such as hypothyroidism (when your thyroid isn’t working enough) or hyperthyroidism (when it’s working too much). It’s often the first test done to evaluate thyroid function, especially if you have symptoms like fatigue, weight changes, or unexplained issues with metabolism.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have fasting instructions depending on your doctor’s protocol, but generally, you can eat and drink normally. Bring any medications you’re taking, as some (like certain thyroid medications) can affect results.

What the Results Mean

TSH results can indicate whether your thyroid is producing too much or too little hormone. High TSH levels often suggest hypothyroidism, while very low levels may indicate hyperthyroidism. Your doctor will interpret results in relation to your symptoms and other tests.

Common Symptoms to Report

If you experience symptoms like unexplained weight changes, fatigue, hair loss, or changes in heart rate, mention them to your doctor before the test. These symptoms can sometimes signal thyroid imbalances that require further evaluation.

Reference range

Adult: 0.4-4.0 mIU/LN/A

Specimen: serum

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

TSH Level

Frequently asked questions

What does a high TSH level usually mean?
A high TSH level often suggests hypothyroidism, meaning your thyroid isn’t producing enough hormones. This can lead to symptoms like fatigue, weight gain, or cold intolerance. Your doctor may recommend further testing or treatment to manage it.
What does a low TSH level usually mean?
A low TSH level may indicate hyperthyroidism or an overactive thyroid, where hormones are produced in excess. Symptoms can include weight loss, rapid heartbeat, or anxiety. Additional tests, like free T4 or antibody checks, may be needed to confirm the diagnosis.
Can medications affect TSH test results?
Yes, certain medications—such as thyroid replacement drugs, steroids, or some antidepressants—can influence TSH levels. Always inform your doctor about all medications you’re taking before the test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy