Skip to content

Thyroid Stimulating Hormone (TSH) with Serum/Plasma Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of thyroid-stimulating hormone (TSH) in your blood. TSH helps regulate your thyroid gland’s activity, which affects metabolism, energy levels, and overall health.

Quick summary

["TSH helps doctors check if your thyroid is working properly and adjusts to hormone imbalances."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50541-2
Short code
TSH 20M p TRH SerPl-aCnc
Synonyms
TSH 20M p TRH SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.4
Ref high
4
Critical range
0.1 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order a TSH test to diagnose or monitor thyroid disorders, such as hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid). It’s often the first test for thyroid issues because it’s sensitive and easy to perform. TSH levels can also be checked during pregnancy, before starting certain medications, or if you have symptoms like fatigue, weight changes, or unexplained mood swings.

What to Expect Before the Test

No special preparation is usually needed, but your doctor might ask you to avoid certain medications (like thyroid hormone replacements) for a few days before testing. If you’re pregnant or breastfeeding, let your healthcare provider know. You’ll typically have a small needle inserted into your arm or a blood sample drawn from your hand or finger.

What the Results Mean

TSH results help determine whether your thyroid is producing too much or too little hormone. High TSH levels often indicate hypothyroidism, while very low levels may suggest hyperthyroidism. Your doctor will compare your results to your symptoms and other tests to make a diagnosis.

Common Symptoms to Watch For

If your TSH levels are abnormal, you might experience symptoms like unexplained fatigue, weight changes (gain or loss), dry skin, hair loss, or depression. Always discuss any symptoms with your doctor, as thyroid issues can affect many parts of your body.

Reference range

Adult: 0.4-4.0 mIU/LN/A

Specimen: serum

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

TSH Level

Frequently asked questions

What does a high TSH level mean?
What does a low TSH level mean?
A low TSH level may indicate an overactive thyroid (hyperthyroidism) or a condition called thyroiditis. Symptoms could include weight loss, anxiety, rapid heartbeat, or tremors. Your doctor will likely order additional tests to confirm the cause and guide treatment.
Can diet affect TSH test results?
Diet alone rarely affects TSH levels, but certain foods or supplements (like soy, selenium, or iodine) may interact with thyroid function. Avoiding large amounts of these for a few days before testing can help ensure accurate results. Always follow your doctor’s instructions.
The frequency depends on your health status. If you have a thyroid disorder, your doctor may recommend regular monitoring. Otherwise, TSH tests are often done once or twice a year for people with risk factors (like family history of thyroid disease) or symptoms. Never skip tests without consulting your healthcare provider.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy