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Thyroid Stimulating Hormone (TSH) with Serum/plasma Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of thyroid-stimulating hormone (TSH) in your blood. TSH helps regulate your thyroid gland’s activity, which is crucial for metabolism, energy levels, and overall health.

Quick summary

["TSH helps your doctor assess thyroid function and identify potential thyroid disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33258-5
Short code
TSH 30M p TRH SerPl-aCnc
Synonyms
TSH 30M p TRH SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.4
Ref high
4
Critical range
0.1 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order a TSH test to check for thyroid problems, such as hypothyroidism (when your thyroid isn’t producing enough hormones) or hyperthyroidism (when it produces too much). It’s often the first test recommended when symptoms like fatigue, weight changes, or unexplained mood swings are present.

How the Test Works

A small blood sample is taken from a vein in your arm. The sample is sent to a lab, where it’s analyzed to measure TSH levels using an immunoassay method. This test helps determine whether your thyroid is functioning normally or if further evaluation is needed.

What to Expect Before the Test

No special preparation is usually required, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader metabolic or hormonal evaluation. Let your doctor know about any medications you’re taking, as some can affect TSH results.

What the Results Mean

Results are interpreted based on your symptoms and overall health. High TSH levels often suggest hypothyroidism, while very low levels may indicate hyperthyroidism. Your doctor will discuss the results with you and may recommend additional tests if needed.

Reference range

Adult: 0.4-4.0 mIU/LN/A

Specimen: serum

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

TSH Level

Frequently asked questions

What does a TSH test help detect?
A TSH test is commonly used to screen for thyroid disorders, including conditions like hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid). It can also help monitor thyroid function in people with known thyroid diseases or those taking thyroid replacement medication.
Can TSH levels change over time?
Yes, TSH levels can fluctuate due to factors like stress, pregnancy, certain medications, or underlying health conditions. If your TSH results are abnormal, your doctor may recommend follow-up testing or adjustments to your treatment plan.
Is fasting required for a TSH test?
No, fasting is generally not required for a standalone TSH test, but it may be advised if the test is part of a broader metabolic or hormonal panel. Always follow your doctor’s specific instructions for your situation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy