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Thyroid Stimulating Hormone (TSH) with Serum/Plasma Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of thyroid-stimulating hormone in your blood, which helps regulate your thyroid function.

Quick summary

["Your TSH level helps doctors check if your thyroid is working properly."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12937-9
Short code
TSH 45M p chal SerPl-aCnc
Synonyms
TSH 45M p chal SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.4
Ref high
4
Critical range
0.1 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84443
SNOMED
301343003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is TSH Used For?

TSH is primarily used to diagnose and monitor thyroid disorders, such as hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid). It’s often the first test recommended if you have symptoms like fatigue, weight changes, or unexplained mood swings.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed using an immunoassay method to measure TSH levels.

What Might Affect Your Results?

Several factors can influence TSH levels, including medications (like thyroid hormone replacement or certain antidepressants), pregnancy, stress, and underlying health conditions. If you’re taking medications or have recent changes in health, let your healthcare provider know.

Common Symptoms Linked to Abnormal TSH Levels

High TSH levels may suggest hypothyroidism, causing symptoms like cold intolerance, dry skin, or weight gain. Low TSH levels might indicate hyperthyroidism, leading to symptoms such as anxiety, rapid heartbeat, or unintended weight loss.

Reference range

Adult: 0.4-4.0 mIU/LN/A

Specimen: serum

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

TSH is a key marker for thyroid function because it signals the thyroid gland to produce thyroid hormones. Abnormal TSH levels can indicate imbalances that require medical attention, such as thyroiditis, pituitary disorders, or autoimmune conditions like Hashimoto’s disease.

Short name

TSH Level

Frequently asked questions

Why did my TSH test result come back different from what I expected?
Your TSH result may vary based on factors like your overall health, medications, or recent stress. If you’re concerned, discuss your results with your doctor—they can help interpret them in the context of your health history.
No special preparation is usually needed, but avoid smoking or drinking alcohol before the test if advised by your doctor. If you’re taking thyroid medication, check with your provider first.
Yes, TSH levels can fluctuate due to natural thyroid changes, aging, or underlying conditions. Regular monitoring may be needed if you have a thyroid disorder or are at risk for thyroid issues.
If your TSH test result is outside the normal range, your doctor may recommend further testing, such as checking free T4 or other thyroid-related markers, to determine the cause and guide treatment.
The frequency depends on your health status. People with thyroid disorders may need testing more often, while others with no known issues may only need occasional checks, especially if they’re at higher risk.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy