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Thyroid Stimulating Hormone (TSH) with Serum/Plasma Electrophoresis Profile

Published: August 9, 2026Updated: August 16, 2026

This test measures your thyroid-stimulating hormone (TSH) level and evaluates protein components in your blood using electrophoresis, which separates different proteins based on size and charge.

Quick summary

["Assesses thyroid function and potential protein abnormalities in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90801-2
Short code
TSH 6h p levo SerPl-aCnc
Synonyms
TSH 6h p levo SerPl-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.4
Ref high
4
Critical range
0.1 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84443
SNOMED
301343003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to check for thyroid disorders, such as hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid). It may also be used to screen for conditions affecting protein levels in the blood, such as multiple myeloma or other blood disorders. Sometimes, it’s part of a broader evaluation if you have symptoms like fatigue, weight changes, or unexplained protein abnormalities.

What to Expect During the Test

A blood sample will be drawn from a vein, usually in your arm. You may feel a slight pinch, but it should only take a few minutes. The blood is then processed to separate proteins and measure TSH levels. No special preparation is needed, but inform your doctor about any medications you’re taking that might affect thyroid function.

What the Results Mean

TSH measures how well your thyroid gland is working. Abnormal results may indicate thyroid hormone imbalances or other blood-related conditions. Protein electrophoresis helps identify specific protein patterns that could signal conditions like infections, cancers, or genetic disorders. Your doctor will interpret these results in the context of your symptoms and medical history.

Common Conditions This Test Helps Diagnose

This test can help diagnose or monitor conditions such as hypothyroidism, hyperthyroidism, protein disorders (e.g., multiple myeloma), and other thyroid or blood-related issues. It may also be used to screen for conditions affecting protein synthesis or thyroid hormone regulation.

Reference range

Adult: 0.4-4.0 mIU/LN/A

Specimen: serum

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated or low TSH levels can signal thyroid dysfunction, which may require treatment like hormone replacement. Abnormal protein patterns detected by electrophoresis can point to conditions like multiple myeloma, where abnormal proteins (e.g., monoclonal gammas) accumulate in the blood. Early detection can improve management and outcomes.

Short name

TSH Profile (Serum/Plasma Electrophoresis)

Frequently asked questions

What does a TSH level alone tell me about my thyroid function?
A TSH test alone provides a snapshot of your thyroid hormone regulation. If your TSH is outside the expected range, it may indicate hypothyroidism (low TSH) or hyperthyroidism (high TSH), but additional tests (like free T4 or antibodies) may be needed for full diagnosis. The electrophoresis portion helps assess protein health, not just thyroid function.
Why would my doctor order both TSH and protein electrophoresis together?
Your doctor may combine these tests if you have symptoms like unexplained fatigue, weight changes, or signs of protein abnormalities (e.g., swelling, frequent infections). The electrophoresis helps rule out blood disorders or metabolic issues that could affect thyroid function indirectly. It’s a comprehensive approach to uncover underlying causes.
Can diet or medications affect the results of this test?
Yes, certain medications (e.g., thyroid hormone replacements, steroids, or lithium) can alter TSH levels. Some foods (e.g., soy, goitrogens) may also impact thyroid function. Always inform your doctor about all medications, supplements, or dietary changes before testing, as they can affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy