Understanding the Complete Blood Count (CBC) Test: A Patient Guide to Your Blood Work Results and What to Expect
A blood test that measures antibodies that block thyroid hormone production, helping diagnose thyroid disorders.
{"Measures antibodies that can prevent thyroid gland from working properly","Helps diagnose the cause of hypothyroidism (underactive thyroid)","Sample is collected from a blood draw","Results help doctors distinguish between autoimmune and non-autoimmune thyroid conditions","May be used to monitor thyroid disease during pregnancy"}
Key facts at a glance
- LOINC
- 14255-4
- Short code
- TSBAb
- Synonyms
- TSH Block Ab Ser-aCnc
- Category
- cardiac
- Sample
- serum
- Container
- Serum separator tube (SST) or plain red top tube
- Units
- N/A
- Ref low
- 10
- Ref high
- 40
- Critical range
- 0.1 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 18 years
- Method
- Immunoassay (Chemiluminescence or ELISA)
- CPT
- 86356
- SNOMED
- 118861001
- Specimen volume
- 1.0-2.0 mL serum
- Stability
- Room temperature: 24-48 hours; Refrigerated (2-8°C): 5-7 days; Frozen (-20°C or below): 30 days
- Hemolysis max
- 50
- Lipemia max
- 300
- Icterus max
- 20
- TAT
- 24–72 hours
- Order
- routine
What is this test, and how can it provide helpful information about your health status?
The Thyrotropin Blocking Antibody (TSBAb) test is a blood test that detects specific antibodies in your blood. These antibodies can block the action of thyroid-stimulating hormone (TSH), which normally tells your thyroid gland to produce thyroid hormones. When these blocking antibodies are present in high levels, they can cause hypothyroidism (an underactive thyroid gland).
Why is this test performed by your doctor, and what conditions can it help diagnose or monitor?
This test is mainly used to help diagnose the cause of hypothyroidism. It can determine whether your thyroid problem is due to an autoimmune condition called Hashimoto's disease or other causes. The test may also be used to distinguish between different types of thyroid disorders and to monitor thyroid function in pregnant women with autoimmune thyroid disease.
How is the test done in the clinic, and what steps will you go through during the procedure?
A healthcare professional will draw a small sample of blood from a vein in your arm. The blood sample is then sent to a laboratory for analysis. You do not need to fast before this test, and there are no special preparations required. The test simply requires a routine blood draw, which takes only a few minutes.
What do the results mean for your treatment plan, and how should you discuss them with your provider?
Results are typically reported as positive or negative, or sometimes as a numerical value with a reference range. A positive result indicates the presence of thyrotropin blocking antibodies, suggesting an autoimmune cause for hypothyroidism. A negative result means these specific antibodies were not detected. Your doctor will interpret these results together with other thyroid tests (such as T3, T4, and TSH) and your clinical symptoms to make an accurate diagnosis.
Reference range
Negative: <10% or <40% (laboratory-specific); Positive: ≥10% or ≥40% (assay-dependent)N/A
No special preparation required. Fasting is not necessary. Inform laboratory of current thyroid medications, immunosuppressants, or recent radiographic contrast procedures.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Thyrotropin blocking antibodies are associated with autoimmune thyroid diseases, particularly Hashimoto's thyroiditis. These antibodies can block TSH from stimulating the thyroid gland, leading to hypothyroidism. Detecting these antibodies helps confirm an autoimmune etiology and can guide treatment decisions. In pregnant women, these antibodies can cross the placenta and affect fetal thyroid function, making this test important for managing thyroid health during pregnancy.
Frequently asked questions
Do I need to fast before this test?
Is this test painful?
How long does it take to get results?
What happens if my test is positive?
Can this test be done during pregnancy?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy