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Understanding the Complete Blood Count (CBC) Test: A Patient Guide to Your Blood Work Results and What to Expect

Published: August 9, 2026Updated: August 16, 2026

A blood test that measures antibodies that block thyroid hormone production, helping diagnose thyroid disorders.

Quick summary

{"Measures antibodies that can prevent thyroid gland from working properly","Helps diagnose the cause of hypothyroidism (underactive thyroid)","Sample is collected from a blood draw","Results help doctors distinguish between autoimmune and non-autoimmune thyroid conditions","May be used to monitor thyroid disease during pregnancy"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14255-4
Short code
TSBAb
Synonyms
TSH Block Ab Ser-aCnc
Category
cardiac
Sample
serum
Container
Serum separator tube (SST) or plain red top tube
Units
N/A
Ref low
10
Ref high
40
Critical range
0.1 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 18 years
Method
Immunoassay (Chemiluminescence or ELISA)
CPT
86356
SNOMED
118861001
Specimen volume
1.0-2.0 mL serum
Stability
Room temperature: 24-48 hours; Refrigerated (2-8°C): 5-7 days; Frozen (-20°C or below): 30 days
Hemolysis max
50
Lipemia max
300
Icterus max
20
TAT
24–72 hours
Order
routine

What is this test, and how can it provide helpful information about your health status?

The Thyrotropin Blocking Antibody (TSBAb) test is a blood test that detects specific antibodies in your blood. These antibodies can block the action of thyroid-stimulating hormone (TSH), which normally tells your thyroid gland to produce thyroid hormones. When these blocking antibodies are present in high levels, they can cause hypothyroidism (an underactive thyroid gland).

Why is this test performed by your doctor, and what conditions can it help diagnose or monitor?

This test is mainly used to help diagnose the cause of hypothyroidism. It can determine whether your thyroid problem is due to an autoimmune condition called Hashimoto's disease or other causes. The test may also be used to distinguish between different types of thyroid disorders and to monitor thyroid function in pregnant women with autoimmune thyroid disease.

How is the test done in the clinic, and what steps will you go through during the procedure?

A healthcare professional will draw a small sample of blood from a vein in your arm. The blood sample is then sent to a laboratory for analysis. You do not need to fast before this test, and there are no special preparations required. The test simply requires a routine blood draw, which takes only a few minutes.

What do the results mean for your treatment plan, and how should you discuss them with your provider?

Results are typically reported as positive or negative, or sometimes as a numerical value with a reference range. A positive result indicates the presence of thyrotropin blocking antibodies, suggesting an autoimmune cause for hypothyroidism. A negative result means these specific antibodies were not detected. Your doctor will interpret these results together with other thyroid tests (such as T3, T4, and TSH) and your clinical symptoms to make an accurate diagnosis.

Reference range

Negative: <10% or <40% (laboratory-specific); Positive: ≥10% or ≥40% (assay-dependent)N/A

Specimen: serum

No special preparation required. Fasting is not necessary. Inform laboratory of current thyroid medications, immunosuppressants, or recent radiographic contrast procedures.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Thyrotropin blocking antibodies are associated with autoimmune thyroid diseases, particularly Hashimoto's thyroiditis. These antibodies can block TSH from stimulating the thyroid gland, leading to hypothyroidism. Detecting these antibodies helps confirm an autoimmune etiology and can guide treatment decisions. In pregnant women, these antibodies can cross the placenta and affect fetal thyroid function, making this test important for managing thyroid health during pregnancy.

Frequently asked questions

Do I need to fast before this test?
No, you do not need to fast before this test. You can eat and drink normally before having your blood drawn.
Is this test painful?
You may feel a brief pinch or sting when the needle is inserted to draw your blood. This discomfort is usually minimal and temporary. After the blood draw, you may have some mild bruising at the injection site.
How long does it take to get results?
Results are typically available within a few days to a week, depending on the laboratory. Your healthcare provider will contact you with the results or discuss them at your follow-up appointment.
What happens if my test is positive?
A positive result means thyrotropin blocking antibodies were detected in your blood. This suggests your hypothyroidism is likely due to an autoimmune condition. Your doctor will use this information, along with other test results and your symptoms, to create an appropriate treatment plan, which usually includes thyroid hormone replacement medication.
Can this test be done during pregnancy?
Yes, this test can be performed during pregnancy. It is sometimes recommended for pregnant women with a history of thyroid autoimmune disease, as these antibodies can potentially affect the developing baby. This helps doctors monitor and manage thyroid function throughout pregnancy.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy