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Thyroid Stimulating Hormone (TSH) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of thyroid-stimulating hormone (TSH) in your blood. TSH helps regulate your thyroid hormone levels, which are crucial for metabolism, energy, and overall health.

Quick summary

["TSH helps assess thyroid function and detect potential thyroid disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110665-7
Short code
TSH Msmt SerPl
Synonyms
TSH Msmt SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.4
Ref high
4
Critical range
0.1 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84443
SNOMED
301343003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order a TSH test to check for thyroid problems, such as hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid). It’s often the first test used to diagnose these conditions because TSH levels can be sensitive indicators of thyroid function.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours before the test if it’s part of a more complex evaluation. Bring any medications you’re taking to your appointment.

What the Results Mean

TSH results can vary based on your health, age, and other factors. High TSH levels often suggest hypothyroidism, while low levels may indicate hyperthyroidism or other conditions affecting thyroid function. Your doctor will interpret results in the context of your medical history and symptoms.

Common Conditions This Test Helps Diagnose

A TSH test can help diagnose or monitor conditions like hypothyroidism (e.g., Hashimoto’s disease), hyperthyroidism (e.g., Graves’ disease), pituitary disorders, and thyroid nodules. It’s also used to check for thyroid hormone imbalances in pregnant women or those with symptoms like fatigue, weight changes, or mood swings.

Reference range

Adult: 0.4-4.0 mIU/LN/A

Specimen: serum

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

TSH Level

Frequently asked questions

What does a high TSH level mean?
A high TSH level often points to an underactive thyroid (hypothyroidism), where the thyroid isn’t producing enough hormones. This can cause symptoms like fatigue, weight gain, or depression. Further tests may be needed to identify the cause, such as antibodies or thyroid hormone levels.
What does a low TSH level mean?
A low TSH level may suggest an overactive thyroid (hyperthyroidism) or other conditions like pituitary issues. Symptoms could include weight loss, rapid heartbeat, or anxiety. Your doctor may recommend additional tests, like free thyroid hormone levels, to clarify the diagnosis.
Can TSH levels change over time?
Yes, TSH levels can fluctuate due to factors like stress, illness, pregnancy, or certain medications. Regular monitoring may be needed if you have a thyroid condition, especially if symptoms or treatment changes occur.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy