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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess overall protein balance and potential liver or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46224-2
Short code
TT P Hpase PPP
Synonyms
TT P Hpase PPP
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag-thrombin-induced-after-addition-of-heparinase
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions like malnutrition, liver disease, kidney problems, or certain infections. It can also help monitor protein loss due to conditions like kidney disease or excessive bleeding.

What Does the Result Mean?

Higher than expected levels might suggest dehydration, multiple myeloma, or certain liver diseases. Lower levels could indicate malnutrition, liver disease, kidney disease, or excessive protein loss.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum (the liquid part after clotting) for testing.

What Are Common Causes of Abnormal Results?

Abnormal results may be linked to dietary issues, chronic diseases like liver or kidney disease, infections, or certain medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein levels can reflect underlying health conditions affecting protein synthesis, absorption, or loss. For example, low levels may indicate severe malnutrition or chronic liver disease, while high levels might suggest dehydration or conditions like multiple myeloma.

Short name

Total Protein

Frequently asked questions

What happens if my total protein test is abnormal?
If your result is outside the expected range, your doctor may recommend further tests or adjustments to your diet, medications, or treatment plan to understand and address the cause.
Can diet affect my total protein test results?
Yes, your diet can influence protein levels. Eating a balanced diet with adequate protein intake can help maintain normal levels. Avoiding excessive alcohol or certain medications may also help stabilize results.
How often should I get this test?
Your doctor will determine how often you need this test based on your health condition and symptoms. Regular follow-ups may be necessary if you have ongoing health issues affecting protein levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy