Skip to content

Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes important substances like albumin and globulins.

Quick summary

["Total protein helps assess overall protein balance and potential liver or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5955-0
Short code
TT PPP Cont
Synonyms
TT PPP Cont
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag-thrombin-induced
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like malnutrition, liver disease, kidney problems, or certain infections. It can also help monitor long-term health in people with chronic illnesses.

What Does a Low or High Result Mean?

Low total protein levels might suggest malnutrition, liver disease, or kidney problems. High levels could indicate dehydration, inflammation, or certain blood disorders.

How Is This Test Performed?

A small blood sample is taken from a vein in your arm. The blood is then sent to a lab where it is processed to measure total protein content.

What Are Common Causes of Abnormal Results?

Changes in total protein can result from diet, medical conditions (like liver disease or kidney failure), medications, or even stress. Chronic illnesses or infections may also affect protein levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What does a normal range for total protein mean for me?
A normal range doesn’t mean your health is perfect—it just means your protein levels are within typical limits for adults. Your actual results will be compared to your specific health needs and any conditions you have.
Can diet affect my total protein test results?
Yes, diet can influence protein levels. Eating a balanced diet with adequate protein intake helps maintain stable results. Avoiding extreme dietary changes before your test can give a more accurate reading.
How often should I get this test?
Your doctor will determine how often you need this test based on your health status, symptoms, or ongoing conditions. Regular monitoring may be recommended for people with chronic illnesses like liver disease or kidney problems.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy