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Tissue Transglutaminase Antibody, Serum (IgA, IgG, IgM)

Published: August 9, 2026Updated: August 16, 2026

This blood test checks for antibodies against tissue transglutaminase, a protein involved in digestion. It helps identify celiac disease or related autoimmune conditions.

Quick summary

["This test may help diagnose conditions linked to gluten sensitivity or autoimmune disorders affecting digestion."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48033-5
Short code
TTR gene Mut Anl Bld/T
Synonyms
TTR gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like persistent diarrhea, stomach pain, weight loss, or fatigue. It’s also used in screening or confirming celiac disease, especially if other tests (like endoscopy or genetic testing) are needed. Rarely, it may be checked in people with other autoimmune conditions like dermatitis herpetiformis.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before drawing blood. Tell your doctor about any medications, supplements, or recent illnesses, as they could affect results.

What the Test Involves

A healthcare provider will insert a needle into a vein in your arm to draw a small amount of blood. The process takes a few minutes and may cause mild discomfort. The blood is then sent to a lab for analysis.

What the Results Mean

High levels of these antibodies often indicate celiac disease or gluten-related disorders. However, results alone aren’t definitive—your doctor will review them with other test results and symptoms to make a diagnosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Tissue Transglutaminase Antibodies

Frequently asked questions

What Are Common Symptoms That Might Lead to This Test?
Symptoms like chronic digestive issues (e.g., bloating, gas, or unexplained weight loss), skin rashes, anemia, or unexplained fatigue may prompt this test, especially if gluten exposure is suspected.
How Does This Test Differ from Other Celiac Disease Tests?
This test measures antibodies against tissue transglutaminase, which can appear earlier than other tests (like endoscopy or genetic testing). It’s often used alongside other markers to confirm or rule out celiac disease.
Can This Test Be Done at Home?
No, this test requires a blood sample drawn by a healthcare professional in a clinical setting. Home-based tests for celiac disease exist but are not the same as this specific antibody test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy