Skip to content

Total IgE Antibody Level (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin E (IgE) antibodies in your blood. IgE is linked to allergic reactions and certain immune responses.

Quick summary

["IgE levels help identify allergies or immune conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39547-5
Short code
Tuna IgE/IgE total %
Synonyms
Tuna IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does IgE Measure?

IgE (Immunoglobulin E) is a type of antibody produced by your immune system in response to allergens, parasites, or infections. High levels may suggest allergies, asthma, or other allergic disorders. This test helps doctors diagnose and monitor these conditions by quantifying your body’s IgE response.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like sneezing, itching, skin rashes, asthma, or if you’ve been exposed to potential allergens. It can also be used to check for conditions like chronic urticaria (hives) or certain parasitic infections.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The blood is then sent to a lab where it is analyzed to measure the total IgE antibody concentration. Results are typically available within a few days.

What Do Results Mean?

Results are compared to a reference range, which varies by lab. Elevated IgE levels may indicate allergies, asthma, or other immune-related conditions. Very low levels might suggest immune deficiencies or certain infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgE Total

Frequently asked questions

What Causes High IgE Levels?
High IgE levels are often linked to allergies (e.g., to pollen, dust, or foods), asthma, or parasitic infections. Rarely, they may indicate autoimmune disorders or certain cancers.
What Causes Low IgE Levels?
Low IgE levels can occur in people with immune system disorders (e.g., hypogammaglobulinemia), certain genetic conditions, or after certain treatments (e.g., chemotherapy). They may also be seen in infants or young children.
How Often Should I Get This Test?
The frequency depends on your symptoms and medical needs. Your doctor may recommend retesting if symptoms change or if treatment is being adjusted.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy