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Vaginal and Genital Microbiome Profile (DNA-Based)

Published: August 9, 2026Updated: August 16, 2026

This test analyzes the DNA from vaginal and genital swabs to identify and assess the types and balance of microbes present, which can help evaluate health or potential infections.

Quick summary

["Understanding your vaginal and genital microbiome can support reproductive and urinary health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
91844-1
Short code
T vaginalis DNA Genital Ql NAA+probe
Synonyms
T vaginalis DNA Genital Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like unusual discharge, itching, odor, or discomfort in the vaginal or genital area. It can also be used for research or monitoring conditions like bacterial vaginosis, sexually transmitted infections (STIs), or other microbial imbalances.

What to Expect During the Test

You’ll collect a sample using a sterile swab from the vaginal or genital region. The sample is then sent to a lab for DNA analysis. No special preparation is needed, but avoid sexual activity or douching 24 hours before the test.

How the Results Are Interpreted

Results show the presence and relative amounts of different microbial DNA. A balanced microbiome typically includes beneficial bacteria like *Lactobacillus*, while harmful bacteria or fungi may indicate an imbalance. Your provider will discuss findings in the context of your symptoms and medical history.

Common Uses and Limitations

This test helps diagnose or monitor infections, track microbial shifts after treatments, or support research. However, it’s not a replacement for traditional culture tests or clinical judgment. Results alone don’t confirm a diagnosis—your provider will interpret them with your full medical picture.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An altered vaginal or genital microbiome can contribute to infections (e.g., yeast infections, bacterial vaginosis), inflammation, or increased risk of STIs. Understanding microbial composition may guide targeted treatments or preventive strategies, though more research is needed to fully standardize clinical use.

Short name

Microbial DNA Profile (Vaginal/Genital Swab)

Frequently asked questions

What does a ‘microbial profile’ mean in this test?
It refers to the DNA analysis of microbes (bacteria, fungi, or other organisms) found in your vaginal or genital area. This profile helps identify which microbes are present and their relative proportions, which can indicate health or potential issues.
Will I need to fast or avoid certain foods before this test?
No fasting or dietary restrictions are required. Avoid sexual activity or douching 24 hours before the test to ensure accurate results.
Can this test detect sexually transmitted infections (STIs) like chlamydia or gonorrhea?
This test primarily assesses the microbiome and may indirectly suggest microbial imbalances linked to infections, but it’s not a direct test for STIs like chlamydia or gonorrhea. Traditional culture or PCR tests are typically used for STI confirmation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy