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Tympanometry Panel with Full Mutational Analysis, Blood or Tissue, Sequencing

Published: August 9, 2026Updated: August 16, 2026

This test combines a tympanometry panel with full mutational analysis using sequencing on a blood or tissue specimen. It is generally used to evaluate middle-ear function alongside genetic changes that may be associated with hearing or ear-related conditions.

Quick summary

["The test pairs a middle-ear function assessment (tympanometry) with genetic sequencing to look for mutations that may help explain ear or hearing findings."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94079-1
Short code
TYMP Full Mut Anl Bld/T Seq
Synonyms
TYMP Full Mut Anl Bld/T Seq
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
sequencing
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is Being Tested

The panel includes tympanometry, which measures how the eardrum and middle-ear system respond to changes in air pressure, giving information about middle-ear function. It also includes full mutational analysis by sequencing, which reads the genetic code of a targeted gene or genes to look for changes (variants). Because the exact gene or genes are set by the ordering laboratory, your clinician can confirm which region is analyzed.

Why Your Clinician May Order It

This test may be ordered when there are concerns about middle-ear function together with a suspected inherited or genetic contribution to hearing or ear problems. It can help connect physical findings from tympanometry with genetic information, supporting diagnosis and counseling.

How the Test Is Performed

Tympanometry is a quick, noninvasive procedure in which a small probe is gently placed in the ear canal to measure eardrum movement as pressure changes. The sequencing portion is done on a specimen such as blood or tissue, from which DNA is extracted and analyzed in the laboratory.

What the Results Can Mean

Tympanometry results describe how well the middle ear is functioning, such as whether there is fluid, stiffness, or normal movement. Sequencing results report whether a genetic variant was found and how it is classified (for example, a variant of uncertain significance versus one with clearer clinical meaning). Your clinician interprets both parts together with your history and other tests; specific numeric ranges and interpretive thresholds vary by laboratory and are not provided here.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinically, combining tympanometry with mutational sequencing can support a more complete evaluation when middle-ear or hearing concerns may have a genetic basis. Sequencing may identify variants that inform diagnosis, family risk, and sometimes management, but results must be interpreted in context because some variants are of uncertain significance and not all changes cause disease.

Frequently asked questions

Does this test replace a standard hearing test?
No. Tympanometry and genetic sequencing provide different information than a hearing (audiometric) evaluation. They are often used alongside, not instead of, other hearing and ear assessments.
Is the sequencing portion the same as whole-genome testing?
Not necessarily. This test involves targeted full mutational analysis of the gene or genes specified by the ordering laboratory. It is not automatically a broad whole-genome or whole-exome test unless the laboratory states that it is.
Could I have a genetic variant and still have normal ear findings?
Yes. A genetic variant does not always produce detectable middle-ear changes, and tympanometry can be normal while a variant is present. Your clinician will interpret results together with your symptoms, family history, and other testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy