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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your blood serum. Proteins are essential for many bodily functions, including transporting nutrients and maintaining fluid balance.

Quick summary

["Your blood protein levels help your body stay healthy by supporting immunity, tissue repair, and fluid balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111828-0
Short code
Type Endscpy
Synonyms
Type Endscpy
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
endoscopy
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order a total protein test to check for conditions affecting protein production, such as liver disease, kidney problems, or certain cancers. It can also help diagnose malnutrition or monitor long-term health in chronic illnesses.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein in your arm for a blood draw. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Higher-than-normal levels might suggest conditions like multiple myeloma, liver disease, or dehydration. Lower-than-normal levels could indicate malnutrition, kidney disease, or severe infections.

Common Conditions Monitored

This test is often used alongside other blood tests to assess overall health, detect hidden infections, or evaluate protein-related disorders like albumin deficiency.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes high total protein?
What causes low total protein?
Low total protein is often linked to malnutrition, kidney disease, liver failure, or severe infections. It can also occur in people with long-term illnesses that deplete protein reserves.
How often should this test be repeated?
Your doctor will determine how often to repeat this test based on your symptoms, medical history, and other test results. If you have a chronic condition, they may schedule follow-ups every few months.
Yes, your diet can influence protein levels. Eating a balanced diet rich in protein (like lean meats, dairy, and legumes) may help maintain stable levels. Avoiding excessive alcohol or extreme diets can also support normal protein function.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy