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Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help support your body’s health and function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34531-4
Short code
Type + XM Pnl Bld
Synonyms
Type + XM Pnl Bld
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order a total protein test to check for conditions affecting protein production, such as liver disease, kidney problems, or certain cancers. It can also help diagnose malnutrition or monitor treatment responses in conditions like multiple myeloma or autoimmune diseases.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Wear a loose shirt for easy access to your arm.

During the Test

A healthcare provider will insert a small needle into a vein in your arm to draw blood. You may feel a slight pinch, but it usually doesn’t cause discomfort. The process takes about 5 minutes.

After the Test

You can resume normal activities immediately. Apply gentle pressure to the site to stop any bleeding, and avoid rubbing it. Check with your provider if you experience excessive bruising or swelling.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

How long does it take to get my results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your healthcare provider will discuss them with you during your follow-up visit.
Can I eat or drink before this test?
If your blood is drawn in the morning, fasting for 8–12 hours is usually recommended. If your test is scheduled later, follow your provider’s specific instructions.
What does it mean if my protein levels are low?
Low protein levels may signal malnutrition, liver or kidney disease, or conditions causing excessive protein loss (e.g., severe infections, certain cancers). Your provider will evaluate your results in the context of your overall health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy