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Urine Tyrosine-to-Creatinine Ratio

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of tyrosine relative to creatinine in urine, helping assess tyrosine metabolism while accounting for urine concentration.

Quick summary

["This urine test helps evaluate whether the body is handling tyrosine normally."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30054-1
Short code
Tyrosine/Creat Ur-Rto
Synonyms
Tyrosine/Creat Ur-Rto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures tyrosine and creatinine in a urine sample and calculates their ratio. Tyrosine is an amino acid, while creatinine is a waste product commonly used to help account for differences in urine concentration.

Why might I need this test?

The test may be used to evaluate suspected inherited disorders of tyrosine metabolism, such as tyrosinemia. It may also be ordered to follow dietary or treatment changes in selected patients.

How is the test performed?

A urine sample is analyzed for tyrosine and creatinine. The laboratory divides the tyrosine result by the creatinine result to calculate the urine tyrosine-to-creatinine ratio.

How do I prepare for the test?

Follow your clinician's instructions about the type and timing of urine collection. Fasting is not usually required, but tell the care team about tyrosine-containing supplements, formula changes, and any other major dietary changes.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine tyrosine/creatinine ratio

Frequently asked questions

Is this the same as a urine protein test?
No. This test measures tyrosine relative to creatinine; it does not directly measure urine protein, albumin, or other substances.
What urine sample is usually needed?
The laboratory may request a first-morning or random urine specimen, depending on the clinical situation. Follow the collection instructions provided with the test order.
Does an abnormal result confirm tyrosinemia?
No. An abnormal ratio can suggest a problem with tyrosine metabolism, but genetic testing, blood tests, and other clinical information may be needed to confirm a diagnosis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy