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Urinary Gene Expression Profile Score (Urinary Gene Expression Score)

Published: August 9, 2026Updated: August 16, 2026

This test measures a calculated score based on the pattern of gene expression found in your urine. It helps assess kidney function and potential early signs of kidney disease or other urinary system conditions.

Quick summary

["This test evaluates kidney health by analyzing gene activity in urine, which may reveal early kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
99959-9
Short code
UC gene expression score Ur
Synonyms
UC gene expression score Ur
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The urinary gene expression score evaluates the activity of specific genes in your urine. Genes are the instructions within your cells that determine how your body functions. By analyzing which genes are active and at what levels, this test can provide insights into kidney health and potential risks for kidney disease or other urinary issues. The score is derived from a combination of these gene expression patterns, rather than measuring a single substance.

Why Might Your Doctor Order This Test?

Your doctor may recommend this test if you have symptoms like changes in urine appearance, persistent pain in your back or sides, unexplained swelling, or if you have a family history of kidney disease. It can also be used to monitor kidney function in people with chronic conditions like diabetes or hypertension. This test helps identify early changes in kidney function that might not be detected by traditional blood or urine tests alone.

How Is This Test Performed?

A small urine sample is collected, typically through standard urine collection methods. The sample is then analyzed in a laboratory using advanced techniques to measure gene expression patterns. The test does not involve invasive procedures or special preparation beyond standard urine collection guidelines.

What Are the Possible Results?

The test produces a numerical score that reflects the overall gene expression profile in your urine. Higher or lower scores may indicate different health conditions, but the exact meaning depends on clinical context, including your medical history and symptoms. Your healthcare provider will interpret the results in relation to your specific situation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

What does this test mean for my health?
This test can help detect early kidney damage or disease by identifying changes in gene expression that occur before traditional blood or urine tests show abnormalities. It may be particularly useful for monitoring kidney health in people at higher risk, such as those with diabetes, hypertension, or a family history of kidney disease. The score can also guide decisions about treatment or lifestyle changes to protect kidney function.
How long will I need to wait for results?
Results from this test are typically available within 1 to 2 weeks after the sample is collected and processed. Your healthcare provider will contact you to discuss the findings once they are ready.
Do I need to prepare for this test?
No special preparation is needed for this test. You may be asked to follow standard urine collection instructions, such as collecting a midstream urine sample in the morning. Avoiding certain medications or foods that could affect urine composition may be recommended by your doctor, but this will be specified if necessary.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy