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Estriol, Maternal Serum (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of estriol, a hormone produced during pregnancy, in your blood. It helps monitor fetal development and health.

Quick summary

["Estriol testing supports prenatal care by assessing fetal well-being and detecting potential complications early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44004-0
Short code
u Estriol MoM Amn
Synonyms
u Estriol MoM Amn
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to evaluate fetal lung maturity, monitor high-risk pregnancies, or investigate unexplained pregnancy complications. Estriol levels can indicate how well the fetus is developing and if there are signs of stress or issues with the placenta.

What to Expect Before the Test

No special preparation is usually needed. You may have a blood sample drawn from a vein in your arm. If you’re pregnant, inform your provider about any medications or supplements you’re taking, as they can sometimes affect test results.

What Happens During the Test?

A healthcare professional will clean the area with an antiseptic, insert a small needle into your vein, and collect a blood sample. The process typically takes a few minutes. You may feel a brief pinch, but most people find it not very uncomfortable.

What Are the Possible Results?

Results are interpreted by your healthcare provider in the context of your pregnancy and medical history. Low estriol levels may suggest fetal distress, placental insufficiency, or other pregnancy-related concerns. High levels might be seen in certain genetic conditions or late-stage pregnancies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Estriol is a hormone produced by the fetus and placenta, and its levels can reflect fetal health and development. Low maternal estriol is often associated with conditions like intrauterine growth restriction, fetal distress, or chromosomal abnormalities. It is commonly used in high-risk pregnancies to guide interventions, such as monitoring fetal lung maturity before birth or assessing placental function.

Short name

Estriol level in maternal blood

Frequently asked questions

How long does it take to get my results?
Results are typically available within a few days to a week, depending on your lab’s processing time. Your healthcare provider will contact you once they have the results and discuss them with you.
What does a low estriol level mean?
A low estriol level may indicate potential fetal or placental issues, such as reduced fetal growth, stress, or certain genetic conditions. Your provider will review the result with you and may recommend further testing or monitoring to ensure your baby’s health.
Can I eat or drink before this test?
You can eat and drink normally before this test unless instructed otherwise by your provider. Blood tests do not require fasting unless specified for other reasons, such as certain hormone tests.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy