Skip to content

Genetic Analysis for UGT1A128 Variant (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks whether you carry a specific genetic variation (UGT1A128) related to how your body processes certain medications or metabolic processes.

Quick summary

["A genetic check for a variant linked to drug metabolism or enzyme function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72508-5
Short code
UGT1A1*28 Bld/T Ql
Synonyms
UGT1A1*28 Bld/T Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test identifies the presence or absence of the UGT1A128 genetic variant in your DNA. This variant is part of the UGT1A gene family, which plays a role in metabolizing drugs and toxins. Your body’s ability to process these substances may differ based on this genetic variation.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of conditions influenced by genetic variations in drug metabolism, such as certain liver enzyme deficiencies or drug interactions. It could also be used before starting medications that rely on UGT1A enzymes for metabolism.

What to Expect Before the Test

No special preparation is needed for this genetic test. A small blood sample is typically taken from your arm, similar to a regular blood draw. The sample is then analyzed in a lab to detect the UGT1A128 variant.

What the Results Mean

Results will indicate whether you carry the UGT1A128 variant. If present, it may affect how your body processes certain medications or metabolic pathways. Your provider will discuss how this finding could influence treatment options or monitoring needs.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

UGT1A128 Genetic Test

Frequently asked questions

How might this test affect my treatment?
If you carry the UGT1A128 variant, your healthcare provider may adjust medication dosages or monitor you more closely, especially if you’re prescribed drugs metabolized by UGT1A enzymes. This variant could also provide insights into how your body handles certain toxins or metabolic processes, though its impact may vary widely among individuals.
Can this test predict health risks beyond drug metabolism?
While the UGT1A128 variant is primarily associated with drug metabolism, it may indirectly influence how your body processes other substances. However, its direct link to specific health risks (like liver disease or certain cancers) is not well established. Always discuss findings with your provider for personalized insights.
Does this test require ongoing monitoring?
Not always. If your variant is detected and linked to medication use, your provider may schedule follow-ups to adjust treatments. Otherwise, this test is typically a one-time or periodic check based on clinical need, such as before starting new medications or during genetic counseling.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy