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UGT1A9 Gene Mutation Status (C2152 Variant)

Published: August 9, 2026Updated: August 16, 2026

This test checks whether a specific genetic variation in the UGT1A9 gene is present in your DNA. The UGT1A9 gene helps your body process certain medications and chemicals.

Quick summary

["This test helps determine if you may have a genetic variation that could affect how your body processes some drugs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104301-7
Short code
UGT1A9 gene.c.-2152C>T Bld/T Ql
Synonyms
UGT1A9 gene.c.-2152C>T Bld/T Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of certain drug-related side effects, such as severe liver reactions or unusual sensitivity to medications like irinotecan. It may also be used in research or genetic counseling contexts.

What the Test Involves

You will provide a small sample of whole blood (a few drops) collected via a simple venipuncture. The sample is then analyzed to check for the presence of the C2152 variant in the UGT1A9 gene.

What the Results Mean

If the variant is found, it means you have this specific genetic change. This information can help guide treatment decisions, especially for medications metabolized by the UGT1A9 enzyme. Results are qualitative (positive or negative) for this variant.

Common Uses and Considerations

This test is primarily used for research, genetic counseling, or in specific clinical scenarios where understanding genetic variations in drug metabolism is critical. It does not replace standard medical testing but may provide additional context for your care plan.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

UGT1A9 Gene Mutation Check

Frequently asked questions

How might this result affect my treatment?
If you are prescribed medications metabolized by the UGT1A9 enzyme, knowing your genetic status may help your doctor adjust your treatment plan to reduce risks of adverse reactions. This is particularly relevant for certain chemotherapy drugs or other medications that rely on this enzyme for metabolism.
What if I have a family member with this variant?
If you have a family history of genetic variations in the UGT1A9 gene, this test can help identify if you carry the same variant. Genetic testing can be important for understanding hereditary risks and planning family health strategies.
Do I need to prepare for this test?
No special preparation is needed. You may eat and drink as usual before the test, and you can continue your normal activities. The blood draw is quick and typically done in a clinic or lab setting.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy