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Urinary Protein-to-Creatinine Ratio (24-Hour Collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein and creatinine in your urine over 24 hours to help assess kidney function and detect proteinuria (excess protein in urine).

Quick summary

["Helps identify kidney issues by checking for protein loss in urine over a full day."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
106022-7
Short code
U parvum DNA Smn Ql NAA+probe
Synonyms
U parvum DNA Smn Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like swelling, frequent urination, or unexplained weight changes. It’s also used to monitor kidney disease, diabetes, or other conditions affecting protein levels in urine.

What to Expect Before the Test

You’ll collect all urine for 24 hours, starting after your first morning void. Store samples in a refrigerator and return them to the lab on time. Drink normal fluids unless instructed otherwise.

How the Test Works

The lab analyzes urine samples for protein concentration and creatinine levels. The ratio helps determine if protein is being lost in urine, which may indicate kidney damage or other health issues.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions like diabetic nephropathy, glomerulonephritis, or nephrotic syndrome, where kidneys may leak protein into urine.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

What does a high or low ratio mean?
A high ratio (protein-to-creatinine ratio) suggests kidney damage or disease, while a low ratio may indicate normal kidney function or conditions like dehydration. Always discuss results with your healthcare provider.
How often should I get this test?
Your doctor will determine frequency based on your health needs—some patients need it yearly, while others may require more frequent checks.
Can I eat or drink anything before the test?
Standard diet and fluids are fine unless your doctor specifies otherwise. Avoid excessive salt or protein-rich foods if instructed, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy