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Valproate (Valproic Acid) in Urine

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of valproate, a medication used to control seizures or mood disorders, in your urine over a 24-hour period.

Quick summary

["Helps monitor medication levels to ensure safety and effectiveness."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73957-3
Short code
UR-144 pentanoate Bld Ql
Synonyms
UR-144 pentanoate Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you’re taking valproate (e.g., Depakote) to check if your levels are within a safe range. It helps prevent toxicity or unnecessary high doses, which could affect your health.

What to Expect Before the Test

No special preparation is needed. You’ll provide a 24-hour urine sample collected in a container, typically starting after your first morning urine. Follow your doctor’s instructions carefully to ensure accurate results.

What the Results Mean

Results are compared to a reference range specific to valproate, but exact values aren’t provided here. High levels may indicate overdose or poor metabolism, while low levels could mean the medication isn’t working as intended.

Possible Side Effects or Risks

Valproate can cause side effects like nausea, dizziness, or stomach upset. Long-term use may increase risks like liver issues or weight gain. Always discuss risks with your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Valproate Level

Frequently asked questions

Why do doctors check urine valproate levels?
Doctors check urine valproate levels to ensure the medication is working safely. High levels can cause toxicity, while low levels may mean the dose isn’t effective. This helps prevent side effects and optimize treatment.
What happens if my urine valproate level is too high?
If your level is too high, your doctor may adjust your dose, switch to a different medication, or monitor you more closely for side effects like nausea, dizziness, or liver issues. They may also recommend blood tests for additional safety checks.
Can I drink alcohol before this test?
No, avoid alcohol before collecting your urine sample. Alcohol can interfere with test results and may affect how your body processes valproate.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy