Skip to content

Uroporphyrin and Creatinine, 24-Hour Urine

Published: August 9, 2026Updated: August 16, 2026

Measures uroporphyrin in a 24-hour urine collection. Paired creatinine measurement helps account for differences in urine concentration.

Quick summary

["This test evaluates urinary uroporphyrin, which can help investigate possible porphyria or impaired liver function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32043-2
Short code
Uropor/Creat 24h Ur-sRto
Synonyms
Uropor/Creat 24h Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures uroporphyrin, a porphyrin-related substance, in urine collected over 24 hours. Creatinine may also be measured to help evaluate how concentrated the urine sample is.

Why might I need this test?

Urine uroporphyrin may be checked when a clinician is evaluating symptoms that could be related to a porphyria, such as unexplained abdominal pain, skin sensitivity, dark-colored urine, or neurologic symptoms. It may also be used in the assessment of certain liver conditions.

How is the test performed?

You collect all urine produced during a full 24-hour period in a designated container. The laboratory then measures uroporphyrin and may use the urine creatinine result to help account for variations in urine concentration.

How do I prepare for the test?

Follow the collection instructions provided by the laboratory, including the exact start and stop times. Tell your clinician about medicines, alcohol use, recent illness, and any changes in urine color, and do not stop prescribed medicines unless instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An increased amount of urinary uroporphyrin may occur with certain forms of porphyria, impaired liver function, or exposure to substances that affect porphyrin metabolism. Medicines, alcohol, smoking, infection, and other health conditions can also influence the result, so an abnormal result requires clinical interpretation rather than a diagnosis by itself.

Short name

24-Hour Urine Uroporphyrin

Frequently asked questions

Why is a 24-hour urine collection used?
It measures substances released throughout the day and can provide a more complete picture than a single urine sample. Complete collection is important for reliable results.
Does the test diagnose porphyria?
No. This test can support further evaluation, but porphyria is usually diagnosed using additional urine, blood, or genetic tests along with symptoms and examination findings.
What if I miss part of the urine collection?
Tell the laboratory or clinician, because an incomplete collection may make the result unreliable. Follow their instructions about restarting the collection.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy