Valproate-Induced Platelet IgM Antibody, Serum/Plasma — Qualitative
This blood test checks for IgM antibodies directed against platelets in response to valproate, which may be associated with immune-related low platelets.
A positive result supports a valproate-related immune reaction affecting platelets.
Key facts at a glance
- LOINC
- 73090-3
- Short code
- Valproate ind plt IgM SerPl Ql FC
- Synonyms
- Valproate ind plt IgM SerPl Ql FC
- Category
- liver
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 44
- Ref high
- 147
- Critical range
- — – 151 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- flow-cytometry
- CPT
- 84075
- SNOMED
- 27550007
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test looks for valproate-induced IgM antibodies that react with platelets, the blood cells involved in clotting. It is performed on a serum or plasma sample and provides a qualitative result.
Why might I need this test?
Your clinician may order this test if you take valproate and develop a low platelet count, unusual bruising, or bleeding. It can help evaluate whether valproate is triggering an immune reaction against platelets.
How is the test performed?
A blood sample is collected, and the laboratory separates serum or plasma for antibody testing. The result is reported as positive or negative based on the laboratory's testing method.
How do I prepare for the test?
No special preparation is usually required. Tell your healthcare team which medicines and doses you are taking, especially if you have recently started or stopped valproate. Do not change your medication without medical advice.
Reference range
Adult: 44-147 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A positive result may indicate a valproate-triggered immune reaction involving platelets and can help explain thrombocytopenia, bruising, or bleeding. A negative result does not completely rule out a medication-related platelet reaction, so results must be interpreted with your symptoms, medication history, and other laboratory findings.
Short name
Valproate-induced platelet IgM antibody
Frequently asked questions
Does a positive result mean valproate should be stopped?
Can this test diagnose immune thrombocytopenia?
What if the result is negative?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy