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Serum Creatinine (Substance Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood serum. It helps assess how well your kidneys are filtering blood.

Quick summary

["Kidney function and waste removal depend on this test result."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94348-0
Short code
VGCC-N Bind IgG+IgM Ser IA-sCnc
Synonyms
VGCC-N Bind IgG+IgM Ser IA-sCnc
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Creatinine Used For?

Creatinine levels help doctors evaluate kidney function. High levels may indicate reduced kidney filtering ability, while low levels could suggest overhydration or muscle disorders.

Why Might This Test Be Ordered?

Your doctor may order this test if you have symptoms like fatigue, swelling, or changes in urine output. It’s also used before surgeries, during pregnancy, or when monitoring chronic conditions like diabetes or heart disease.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis to measure creatinine concentration.

What Do Results Mean?

Results are compared to a reference range specific to your age, sex, and health status. Abnormal levels may signal kidney issues or other health concerns.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels are a key indicator of kidney function. Elevated levels often signal impaired kidney function, which can lead to complications like fluid buildup, electrolyte imbalances, or worsening of chronic diseases. Low levels may require further investigation to rule out conditions like dehydration or muscle wasting.

Short name

Creatinine Level

Frequently asked questions

What causes creatinine levels to change?
Creatinine levels can rise due to kidney disease, dehydration, or conditions that reduce muscle mass. They may drop with overhydration, certain medications, or muscle disorders.
How often should I get this test?
Your doctor will determine how often you need this test based on your health status, medications, and symptoms. Regular monitoring may be needed if you have kidney disease or other chronic conditions.
Can diet or exercise affect creatinine levels?
Yes, diet high in protein can temporarily increase creatinine levels. Exercise generally does not affect creatinine levels directly, but it may influence overall kidney health indirectly.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy