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Vitamin K-dependent clotting factors (Prothrombin Complex Concentrate, PCC) activity measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures how well your blood can clot in response to vitamin K-dependent clotting factors, often used to assess bleeding risks or after certain treatments.

Quick summary

["Helps monitor bleeding disorders or effectiveness of vitamin K replacement therapy."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
68943-0
Short code
VGKC Ab Ser-aCnc
Synonyms
VGKC Ab Ser-aCnc
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test evaluates the activity of vitamin K-dependent clotting factors (such as factors II, VII, IX, and X) in your blood. These factors are essential for normal clotting. The result helps determine how well your blood can form clots under specific conditions.

Why It’s Ordered

Your healthcare provider may order this test if you have bleeding problems, are taking medications that affect clotting (like warfarin), or are receiving vitamin K replacement therapy. It’s also used before surgeries or procedures where bleeding risk is high.

Sample Collection and Preparation

A blood sample is taken from a vein, usually in your arm. The sample is processed to separate plasma, which is then analyzed for clotting factor activity under controlled conditions.

What to Expect Before the Test

No special preparation is needed, but inform your provider about any medications (including supplements) or recent illnesses that could affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

PCC Activity Test

Frequently asked questions

What does a low or high result mean?
A low result may suggest bleeding disorders, liver disease, or vitamin K deficiency. A high result could indicate overactive clotting or laboratory error. Your provider will interpret results in the context of your overall health.
How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on lab processing times.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise by your provider, as fasting is not required for this test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy