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Vitamin K-dependent clotting factor activity profile (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity levels of blood clotting factors that depend on vitamin K, which helps assess bleeding risks or deficiencies.

Quick summary

["Checks how well your blood can clot due to vitamin K’s role in key clotting proteins."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94816-6
Short code
VGKC Ab Ser IA-sCnc
Synonyms
VGKC Ab Ser IA-sCnc
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like excessive bleeding (e.g., bruising, nosebleeds, or heavy menstrual periods), unexplained bleeding after surgery, or if you’re taking blood thinners. It can also help diagnose conditions like vitamin K deficiency or liver disease that affect clotting.

What to Expect Before the Test

No special preparation is needed, but inform your healthcare provider about any medications (especially blood thinners) or recent surgeries. Avoid eating or drinking anything (except water) for 12 hours before the test if instructed.

How the Test Is Performed

A blood sample is drawn from a vein in your arm by a healthcare professional. The blood is sent to a lab where it’s analyzed for clotting factor activity levels using specialized tests.

Test Results and Interpretation

Results show the activity levels of specific clotting factors (e.g., factors II, VII, IX, X) compared to a standard. Abnormal results may indicate bleeding disorders, vitamin K deficiency, or liver problems.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low levels of these factors can signal bleeding risks, while high levels may suggest conditions like liver disease or certain blood disorders. This test helps guide treatment for bleeding disorders, vitamin K supplementation, or management of blood thinners.

Short name

Vitamin K Factor Profile

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times.
Can I eat or drink before this test?
Follow your doctor’s instructions—usually, avoid food/drink (except water) for 12 hours before testing, but confirm with your provider.
Does this test require fasting?
Yes, fasting may be required, but your doctor will specify if it applies to this test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy