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Vitamin K-dependent clotting factor activity profile (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity levels of key blood clotting factors that depend on vitamin K, helping assess bleeding risks or deficiencies.

Quick summary

["Checks vitamin K’s role in blood clotting function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
41871-5
Short code
VGKC Ab Ser-sCnc
Synonyms
VGKC Ab Ser-sCnc
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Vitamin K is essential for producing several proteins that help your blood clot properly. If you have a vitamin K deficiency, your blood may clot too slowly, increasing the risk of excessive bleeding. This test helps doctors evaluate whether your body is producing enough of these clotting factors.

What to Expect Before the Test

No special preparation is needed unless instructed by your healthcare provider. You may have a blood draw from a vein in your arm, similar to other blood tests. If you’re on blood thinners, let your doctor know before the test.

Common Reasons for Testing

Doctors may order this test if you have bleeding problems, surgery planned, or signs of vitamin K deficiency (like bruising easily or bleeding gums). It’s also used to monitor treatment for conditions like liver disease or certain medications.

What the Results Mean

Results show the activity levels of specific clotting factors (e.g., prothrombin, factor VII, X). Lower-than-normal levels may indicate vitamin K deficiency or liver issues. Your doctor will interpret results in the context of your medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal results can signal bleeding disorders, liver disease, malabsorption issues (like celiac disease), or vitamin K deficiency. High levels may suggest overuse of certain medications. Always discuss results with your healthcare provider to determine the next steps.

Short name

Vitamin K Clotting Factors

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time.
What does a low result mean?
A low result may mean your blood isn’t clotting as well as it should, which could be due to vitamin K deficiency, liver problems, or certain medications. Your doctor will help explain what this means for your health.
Can diet affect this test?
Yes, foods rich in vitamin K (like leafy greens, broccoli, and some oils) can influence results. Avoid large changes to your diet before testing unless advised by your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy