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Collagen Type III Mass Concentration (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a specific protein called collagen type III in your blood. Collagen is a key structural protein found in connective tissues, including skin, blood vessels, and organs.

Quick summary

["Collagen type III helps maintain the strength and integrity of your blood vessels and other tissues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
38509-6
Short code
Visc 30M p coll Smn Ql
Synonyms
Visc 30M p coll Smn Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions that could involve abnormal collagen type III levels, such as vascular diseases, connective tissue disorders, or certain types of scarring or tissue damage. It may also be part of a broader evaluation for conditions like Ehlers-Danlos syndrome or other genetic connective tissue disorders.

What to Expect Before the Test

No special preparation is typically needed for this blood test. You may fast for 8–12 hours before the draw if instructed by your provider, but always follow their specific instructions. Bring any medications or supplements you’re taking, as they may affect results.

What Happens During the Test

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a slight pinch, but the procedure usually takes just a few minutes. The blood sample is then sent to a lab for analysis using a specialized technique to measure collagen type III.

What the Results Mean

Results are reported as a mass concentration (e.g., grams per liter). While reference ranges vary by lab, elevated levels may suggest conditions affecting collagen production or vascular integrity, while very low levels could indicate genetic disorders or tissue damage. Your provider will interpret results in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Collagen III Level

Frequently asked questions

What causes collagen type III levels to change?
Collagen type III levels can be influenced by genetic factors, certain medical conditions (like vascular diseases or connective tissue disorders), medications, or even lifestyle factors such as smoking or chronic stress. If your levels are abnormal, your provider may investigate underlying causes, including family history or other health conditions.
How often should I get this test?
The frequency of this test depends entirely on your healthcare provider’s recommendations. They may order it once as part of a diagnostic evaluation or schedule follow-ups if you have ongoing symptoms or conditions linked to collagen-related disorders. Never adjust your schedule without their guidance.
Can diet or supplements affect collagen type III test results?
Some supplements (like collagen peptides or vitamin C) may indirectly support collagen production, but they do not directly influence this specific test. Follow your provider’s instructions regarding fasting or avoiding certain foods if they recommend it. Always disclose all supplements you take to your healthcare provider before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy