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Vitamin B12 (Serum or Plasma Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of vitamin B12, a crucial nutrient needed for healthy nerve function and red blood cell production, in your blood.

Quick summary

["Assesses vitamin B12 deficiency, which can affect energy levels and nerve health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96808-1
Short code
Vit B1 IgE Qn
Synonyms
Vit B1 IgE Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Vitamin B12 is essential for preventing anemia, maintaining nerve function, and supporting DNA synthesis. Low levels may indicate poor absorption, dietary deficiencies, or underlying health conditions.

What to Expect During the Test

A blood sample is drawn from a vein, usually in your arm. The test is quick and typically done in a lab setting. You may feel slight discomfort, but it usually doesn’t require special preparation.

Low vitamin B12 levels can result from dietary insufficiency, conditions like pernicious anemia, or malabsorption issues. High levels are less common but may occur with certain medications or genetic disorders.

Symptoms may include fatigue, weakness, numbness or tingling in hands/feet, balance problems, or memory issues. Some people have no symptoms until deficiency is severe.

Results are compared to a reference range provided by your healthcare provider. While ranges vary by lab, low values may trigger further testing or dietary adjustments.

If your results are low, your doctor may recommend dietary changes, vitamin supplements, or additional tests to identify the cause. High levels may require further evaluation to rule out rare conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Vitamin B12 Level

Frequently asked questions

How often should I get this test?
Your doctor will determine the frequency based on your health history, symptoms, and risk factors. Typically, it’s not a routine screening test unless you have symptoms or risk factors for deficiency.
What can I do to support healthy vitamin B12 levels?
Eat a balanced diet rich in vitamin B12 (found in animal products like meat, fish, eggs, and dairy). If you follow a vegetarian or vegan diet, consult your doctor about supplements or fortified foods.
Does stress or diet affect vitamin B12 levels?
Chronic stress or poor nutrition can contribute to deficiency, but stress alone doesn’t directly alter B12 levels. Dietary habits and absorption issues play the biggest role.
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Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy